Iso Aret 20mg Capsule contains isotretinoin, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that has not responded adequately to conventional therapies such as systemic antibiotics. Isotretinoin exerts its therapeutic effect by reducing sebaceous gland size and sebum production, normalizing follicular keratinization, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors involved in acne development. Each capsule delivers 20mg of isotretinoin, administered orally, with dosing individualized based on patient weight and clinical response, typically ranging from 0.5 to 1 mg/kg/day in divided doses. Treatment duration usually spans 15 to 20 weeks, with careful monitoring to minimize adverse effects. Common side effects include dry skin, cheilitis, and transient elevations in liver enzymes and lipid profiles; hence, regular laboratory assessments are recommended. Due to its high teratogenic potential, Iso Aret is contraindicated in pregnancy, and strict contraceptive measures must be enforced for women of childbearing potential before, during, and after therapy. Patients should avoid vitamin A supplements and exposure to excessive sunlight or UV radiation during treatment. Iso Aret 20mg Capsule should be prescribed and used under specialist supervision to ensure safety and efficacy.