Isek 5 Softgel Capsule contains isotretinoin 5 mg, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as systemic antibiotics and topical treatments. Isotretinoin exerts its therapeutic effect by reducing sebaceous gland size and sebum production, normalizing follicular keratinization, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors of acne. The softgel formulation ensures optimal bioavailability and patient compliance. Isek 5 should be administered under strict medical supervision due to its potent teratogenicity and potential for serious adverse effects, including hepatotoxicity, hyperlipidemia, and mucocutaneous reactions. Baseline and periodic monitoring of liver function tests, lipid profile, and complete blood counts are recommended during therapy. Patients must adhere to pregnancy prevention protocols, including reliable contraception, and undergo regular pregnancy testing before and during treatment. Dose adjustments may be necessary based on clinical response and tolerability. Isek 5 is contraindicated in pregnancy, hypersensitivity to isotretinoin or any capsule components, and in patients with pre-existing hepatic or lipid metabolism disorders. Proper patient education regarding the risks, benefits, and necessary precautions is essential to ensure safe and effective use of isotretinoin therapy.