Isek 30 Softgel Capsule contains isotretinoin 30 mg, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics. Isotretinoin exerts its therapeutic effect by reducing sebaceous gland size and sebum production, inhibiting comedogenesis, and exhibiting anti-inflammatory properties, thereby addressing multiple pathogenic factors of acne. The softgel formulation ensures optimal bioavailability and ease of administration. Due to its teratogenic potential, Isek 30 must be prescribed with caution, particularly in women of childbearing potential, who should adhere to strict contraceptive measures before, during, and after treatment. Common adverse effects include dry skin, cheilitis, conjunctivitis, and transient elevations in liver enzymes and lipid profiles; therefore, regular monitoring of liver function tests and lipid panels is recommended throughout therapy. Patients should avoid excessive sun exposure and use appropriate skin moisturizers to mitigate dryness. Isek 30 is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with pre-existing hepatic or lipid abnormalities. This medication should be used under close medical supervision, with dosage adjustments based on clinical response and tolerability to achieve optimal outcomes in severe acne management.