Instoid 20 Soft Gelatin Capsule contains Isotretinoin 20 mg, a potent retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin exerts its therapeutic effects by reducing sebaceous gland size and sebum production, normalizing follicular keratinization, and exhibiting anti-inflammatory properties, thereby targeting multiple pathogenic factors involved in acne development. This medication is administered orally, with dosage individualized based on patient weight, severity of condition, and response to treatment. Due to its teratogenic potential, strict adherence to pregnancy prevention measures is mandatory for female patients of childbearing potential before, during, and after therapy. Common adverse effects include mucocutaneous dryness, cheilitis, elevated liver enzymes, and lipid abnormalities, necessitating regular monitoring of liver function tests and lipid profiles throughout treatment. Patients should avoid excessive sun exposure and use appropriate skin moisturizers to manage dryness. Instoid 20 should be prescribed and monitored by healthcare professionals experienced in isotretinoin therapy to ensure optimal efficacy and minimize risks. It is contraindicated in pregnancy, breastfeeding, and patients with hypersensitivity to isotretinoin or any capsule components.