Ibitret 20mg Capsule contains isotretinoin, a potent retinoid primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as systemic antibiotics and topical treatments. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of acne-causing bacteria, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. Each capsule delivers 20mg of isotretinoin, administered orally, with dosage individualized based on patient weight and clinical response, typically ranging from 0.5 to 1 mg/kg/day divided into two doses over a 15- to 20-week course. Due to its teratogenic potential, strict pregnancy prevention measures must be implemented before, during, and after treatment. Patients should be monitored regularly for adverse effects, including mucocutaneous dryness, elevated liver enzymes, lipid abnormalities, and mood changes. Liver function tests and lipid profiles are recommended at baseline and periodically throughout therapy. Ibitret is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with severe hepatic or renal impairment. This medication should be prescribed and supervised by a healthcare professional experienced in managing isotretinoin therapy to ensure safe and effective use.