I-Sure Capsule contains Isotretinoin 20 mg, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics and topical agents. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of Propionibacterium acnes, and exerting anti-inflammatory effects. The capsule formulation ensures precise dosing and optimal bioavailability. I-Sure Capsule is prescribed under strict medical supervision due to its potential for serious adverse effects, including teratogenicity, hepatotoxicity, and lipid abnormalities. Patients should undergo baseline and periodic monitoring of liver function tests, lipid profiles, and complete blood counts during therapy. It is contraindicated in pregnancy and in women planning to conceive during treatment and for at least one month after discontinuation. Patients must adhere to effective contraception measures. Common side effects include dry skin, cheilitis, and mucosal dryness. Dose adjustments may be necessary based on tolerability and clinical response. I-Sure Capsule should be used as part of a comprehensive acne management plan, including patient education on adherence and monitoring. Healthcare professionals must evaluate risk-benefit ratio before initiating therapy.