I Deriva 20mg Capsule contains isotretinoin, a retinoid derivative used primarily for the treatment of severe recalcitrant nodular acne that has not responded to conventional therapies such as antibiotics. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the growth of acne-causing bacteria, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors of acne. This medication is indicated for patients with severe cystic or nodular acne and other dermatological conditions as determined by a healthcare professional. I Deriva 20mg Capsule should be administered under strict medical supervision due to its potential for serious adverse effects, including teratogenicity, hepatotoxicity, and lipid abnormalities. Patients must undergo regular monitoring of liver function tests, lipid profiles, and pregnancy status in females of childbearing potential. Common side effects include dry skin, cheilitis, and photosensitivity. Due to its teratogenic risk, effective contraception is mandatory before, during, and after treatment. Dosage and duration of therapy should be individualized based on clinical response and tolerability. Patients are advised to avoid vitamin A supplements and to report any adverse symptoms promptly. I Deriva 20mg Capsule is a potent therapeutic option for severe acne when used responsibly and in accordance with prescribing guidelines.