Gramocef-OF Tablet is a combination antibiotic formulation containing Cefixime 200 mg and Ofloxacin 200 mg, designed for the treatment of a broad spectrum of bacterial infections. Cefixime, a third-generation cephalosporin, acts by inhibiting bacterial cell wall synthesis, leading to cell lysis and death, while Ofloxacin, a fluoroquinolone, exerts its bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and transcription. This synergistic combination enhances efficacy against both Gram-positive and Gram-negative pathogens, including strains resistant to monotherapy. Gramocef-OF is indicated for respiratory tract infections, urinary tract infections, gastrointestinal infections, skin and soft tissue infections, and sexually transmitted infections caused by susceptible organisms. The tablet should be administered as prescribed by a healthcare professional, typically once or twice daily, with or without food. Caution is advised in patients with a history of hypersensitivity to cephalosporins or fluoroquinolones, and it is contraindicated in individuals with known tendon disorders related to fluoroquinolone use. Potential side effects include gastrointestinal disturbances, hypersensitivity reactions, and, rarely, tendonitis or tendon rupture. Proper adherence to the prescribed dosage and duration is essential to prevent antibiotic resistance and ensure therapeutic success.