Glotret 5mg Tablet contains isotretinoin, a retinoid derivative primarily indicated for the treatment of severe recalcitrant nodular acne that is unresponsive to conventional therapies such as antibiotics. Isotretinoin acts by reducing sebaceous gland size and sebum production, inhibiting the proliferation of Propionibacterium acnes, and exerting anti-inflammatory effects, thereby addressing multiple pathogenic factors in acne development. Glotret should be prescribed under strict medical supervision due to its potent teratogenicity and risk of serious adverse effects. Prior to initiation, pregnancy must be excluded, and effective contraception is mandatory for female patients of childbearing potential. Common side effects include cheilitis, dry skin, and mucous membrane irritation, while more severe adverse reactions may involve hepatotoxicity, hyperlipidemia, and mood alterations. Regular monitoring of liver function tests, lipid profile, and complete blood counts is recommended throughout the treatment course. Dosage should be individualized based on patient response and tolerability, with typical regimens ranging from 0.5 to 1 mg/kg/day divided into two doses. Glotret is contraindicated in pregnancy, hypersensitivity to isotretinoin, and patients with pre-existing hepatic or lipid metabolism disorders. Patient education on adherence, potential side effects, and avoidance of vitamin A supplementation is essential to optimize therapeutic outcomes and minimize risks.