Genxment-NP Tablet SR is a sustained-release formulation combining Pregabalin (75mg), Nortriptyline (10mg), and Methylcobalamin (1500mcg), designed for the management of neuropathic pain and associated conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels in the central nervous system, reducing neurotransmitter release and alleviating neuropathic pain symptoms. Nortriptyline, a tricyclic antidepressant, exerts analgesic effects by inhibiting the reuptake of norepinephrine and serotonin, thereby enhancing descending inhibitory pain pathways. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair, contributing to improved nerve function and symptomatic relief. The sustained-release formulation ensures prolonged therapeutic action, enhancing patient compliance by reducing dosing frequency. Genxment-NP is indicated for diabetic peripheral neuropathy, post-herpetic neuralgia, and other chronic neuropathic pain syndromes. It should be used under medical supervision, considering potential side effects such as dizziness, somnolence, dry mouth, and gastrointestinal disturbances. Dose adjustments may be necessary in renal impairment. Contraindications include hypersensitivity to any component and caution in patients with cardiac conduction abnormalities or a history of seizures. Regular monitoring is advised to optimize therapeutic outcomes and minimize adverse effects. Genxment-NP Tablet SR offers a multi-modal approach to neuropathic pain management by combining analgesic, antidepressant, and neurotrophic agents in a single dosage form.