Ztokem Injection contains Aztreonam 2000 mg, a synthetic monocyclic beta-lactam antibiotic belonging to the monobactam class. It is indicated for the treatment of serious Gram-negative bacterial infections, including those caused by Pseudomonas aeruginosa, Escherichia coli, Klebsiella species, and other susceptible aerobic Gram-negative pathogens. Aztreonam exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to penicillin-binding proteins, leading to cell lysis and death. Ztokem Injection is particularly useful in patients with penicillin allergies due to its minimal cross-reactivity with other beta-lactam antibiotics. The formulation is intended for intravenous or intramuscular administration, allowing for rapid systemic distribution. Dosage and duration of therapy should be individualized based on the severity of infection, renal function, and clinical response. Adverse reactions may include local injection site reactions, rash, gastrointestinal disturbances, and, rarely, hypersensitivity reactions. Caution is advised in patients with a history of hypersensitivity to beta-lactams. Monitoring renal function during prolonged therapy is recommended to adjust dosing appropriately. Ztokem Injection should be used under strict medical supervision to ensure optimal therapeutic outcomes and minimize the risk of resistance development.