Zorem-HT 10 Tablet is a combination antihypertensive medication containing Ramipril 10 mg and Hydrochlorothiazide 12.5 mg. Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, works by blocking the conversion of angiotensin I to angiotensin II, leading to vasodilation, reduced aldosterone secretion, and decreased blood pressure. Hydrochlorothiazide, a thiazide diuretic, promotes the excretion of sodium and water by inhibiting sodium reabsorption in the distal convoluted tubules of the kidneys, thereby reducing blood volume and peripheral resistance. This synergistic combination effectively manages hypertension, reducing the risk of cardiovascular events such as stroke, myocardial infarction, and heart failure. Zorem-HT 10 is indicated for patients whose blood pressure is not adequately controlled with monotherapy. It should be used with caution in patients with renal impairment, electrolyte imbalances, or a history of angioedema. Common adverse effects may include dizziness, hypotension, electrolyte disturbances, and dry cough. Regular monitoring of blood pressure, renal function, and serum electrolytes is recommended during therapy. Zorem-HT 10 Tablet should be administered once daily, preferably at the same time each day, and adherence to lifestyle modifications is advised to optimize therapeutic outcomes.