Zootem-DSR Capsule is a combination pharmaceutical formulation containing Domperidone 30 mg and Pantoprazole 40 mg, indicated for the management of gastroesophageal reflux disease (GERD), dyspepsia, and related upper gastrointestinal disorders. Domperidone, a peripheral dopamine D2 receptor antagonist, facilitates gastric motility and accelerates gastric emptying, thereby alleviating symptoms such as nausea, vomiting, and bloating. Pantoprazole, a proton pump inhibitor (PPI), suppresses gastric acid secretion by inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells, providing effective acid control and promoting mucosal healing. The synergistic action of these agents offers symptomatic relief and addresses the underlying pathophysiology of acid-related disorders. Zootem-DSR is typically administered orally, once daily before meals, with dosage adjustments based on clinical response and patient tolerance. It is contraindicated in patients with known hypersensitivity to either component and should be used cautiously in individuals with hepatic impairment. Common adverse effects may include headache, dry mouth, abdominal discomfort, and rare extrapyramidal symptoms. This combination therapy enhances patient compliance by reducing pill burden and improving therapeutic outcomes in acid-peptic conditions. Prior consultation with a healthcare professional is recommended to ensure appropriate use and monitoring.