Zolocin Tablet is a combination antibiotic formulation containing Ofloxacin 200 mg and Ornidazole 500 mg, designed for the treatment of a broad spectrum of bacterial and protozoal infections. Ofloxacin, a fluoroquinolone antibiotic, exerts its bactericidal action by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby preventing DNA replication and transcription. Ornidazole, a nitroimidazole derivative, is effective against anaerobic bacteria and protozoa by disrupting DNA synthesis and inducing strand breakage. This synergistic combination is particularly useful in managing mixed infections involving both aerobic and anaerobic pathogens, such as gastrointestinal infections, genitourinary tract infections, and certain respiratory tract infections. Zolocin Tablet is indicated for conditions including bacterial dysentery, amoebiasis, trichomoniasis, and pelvic inflammatory disease. The recommended dosage and duration of therapy should be tailored according to the severity and type of infection, as well as patient-specific factors. Caution is advised in patients with a history of hypersensitivity to fluoroquinolones or nitroimidazoles, and in those with hepatic or renal impairment. Adverse effects may include gastrointestinal disturbances, headache, dizziness, and, rarely, tendonitis or neuropathy. Proper adherence to prescribed dosing is essential to prevent resistance development and ensure therapeutic efficacy.