Zinderm - Bpo Gel is a topical dermatological formulation containing Adapalene 0.1% w/w and Benzoyl Peroxide 2.5% w/w, indicated for the treatment of acne vulgaris. Adapalene, a third-generation retinoid, exerts its therapeutic effect by modulating cellular differentiation and keratinization, thereby preventing the formation of microcomedones and promoting the normalization of follicular epithelial desquamation. Benzoyl Peroxide, a potent antibacterial and keratolytic agent, reduces Propionibacterium acnes colonization and facilitates the removal of comedones through its mild exfoliating properties. The combination of these active ingredients provides a synergistic effect, targeting multiple pathogenic factors in acne development, including inflammation, bacterial proliferation, and abnormal keratinization. Zinderm - Bpo Gel is typically applied once daily to the affected areas, ensuring the skin is clean and dry prior to application. Common adverse effects may include mild to moderate skin irritation, erythema, dryness, and peeling, which usually diminish with continued use. Patients are advised to avoid excessive sun exposure and use sunscreen during treatment. This gel formulation offers an effective and well-tolerated option for patients with mild to moderate inflammatory and non-inflammatory acne lesions, improving skin appearance and reducing lesion count over time.