Zenfate Oral Suspension Orange Sugar Free is a combination pharmaceutical formulation containing Sucralfate 1000 mg/ml and Oxetacaine 20 mg/ml, designed for the effective management of gastrointestinal mucosal lesions and associated pain. Sucralfate acts as a cytoprotective agent by forming a viscous, adhesive barrier on ulcer sites, thereby protecting the mucosa from acid, pepsin, and bile salts, which facilitates healing of gastric and duodenal ulcers. Oxetacaine, a local anesthetic, provides rapid symptomatic relief by numbing the mucosal surface, reducing pain and discomfort associated with esophagitis, gastritis, and peptic ulcer disease. The orange-flavored, sugar-free suspension enhances patient compliance, particularly in individuals with sugar restrictions such as diabetics. Zenfate is indicated for the treatment and symptomatic relief of gastric and duodenal ulcers, gastroesophageal reflux disease (GERD), and other acid-related mucosal irritations. It is administered orally, with dosage tailored according to clinical response and severity of symptoms. Caution is advised in patients with renal impairment due to aluminum content from Sucralfate. Adverse effects are generally mild and may include constipation or dry mouth. Zenfate Oral Suspension Orange Sugar Free offers a dual mechanism of action, combining mucosal protection and analgesia for comprehensive management of upper gastrointestinal mucosal conditions.