Zeez-M 5mg/10mg Tablet is a combination medication containing Levocetirizine 5mg and Montelukast 10mg, primarily indicated for the management of allergic conditions such as allergic rhinitis and chronic urticaria. Levocetirizine, a third-generation non-sedating antihistamine, selectively inhibits peripheral H1 receptors, thereby alleviating symptoms like sneezing, nasal congestion, itching, and rhinorrhea. Montelukast, a leukotriene receptor antagonist, blocks the action of leukotrienes, inflammatory mediators involved in bronchoconstriction and airway inflammation, making it effective in preventing asthma symptoms and improving respiratory function. The synergistic effect of these two agents provides comprehensive relief from both upper and lower airway allergic manifestations. Zeez-M is generally well-tolerated; common adverse effects may include headache, fatigue, dry mouth, and gastrointestinal disturbances. It is contraindicated in patients with known hypersensitivity to any component of the formulation. Caution is advised in patients with hepatic or renal impairment, and dosage adjustments may be necessary. This combination should be used under medical supervision, especially in pediatric and elderly populations. Zeez-M offers an effective therapeutic option for patients requiring dual-action treatment targeting histamine-mediated and leukotriene-mediated allergic responses.