Yuvisef-O Tablet is a combination antibiotic formulation containing Ofloxacin 200 mg and Ornidazole 200 mg, indicated for the treatment of mixed bacterial and protozoal infections. Ofloxacin, a fluoroquinolone antibiotic, exerts its bactericidal action by inhibiting bacterial DNA gyrase and topoisomerase IV, thereby preventing DNA replication and transcription. Ornidazole, a nitroimidazole derivative, is effective against anaerobic bacteria and protozoa by disrupting DNA synthesis and causing cell death. This synergistic combination is commonly prescribed for infections such as gastrointestinal infections, genitourinary tract infections, respiratory tract infections, and certain sexually transmitted infections where both aerobic and anaerobic pathogens are suspected. Yuvisef-O is particularly useful in managing complicated infections involving mixed flora. The tablet should be administered as per the prescribed dosage regimen, typically twice daily, and treatment duration should be adhered to strictly to prevent resistance development. Caution is advised in patients with known hypersensitivity to fluoroquinolones or nitroimidazoles, and use should be avoided during pregnancy and lactation unless deemed essential by a healthcare professional. Common side effects may include gastrointestinal disturbances, headache, dizziness, and hypersensitivity reactions. Renal and hepatic function monitoring is recommended during prolonged therapy.