Xenadom 250 Tablet is a combination medication containing Naproxen 250 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for inflammation, pain, and fever. Domperidone, a dopamine antagonist, enhances gastrointestinal motility and accelerates gastric emptying, which helps alleviate nausea and vomiting often associated with pain or NSAID therapy. Xenadom 250 is indicated for the management of acute and chronic musculoskeletal pain, dysmenorrhea, and inflammatory conditions where pain relief is required alongside mitigation of gastrointestinal side effects. The combination improves patient compliance by addressing both pain and nausea in a single dosage form. It is recommended to be taken orally with or after food to minimize gastrointestinal irritation. Caution is advised in patients with a history of peptic ulcers, cardiovascular disease, or hepatic impairment. Use during pregnancy and lactation should be under medical supervision. Common adverse effects may include gastrointestinal discomfort, dizziness, or dry mouth. Xenadom 250 Tablet should be used as directed by a healthcare professional to ensure safety and efficacy.