Zerograin-Plus New Tablet is a combination medication containing Naproxen 250 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins involved in inflammation and pain signaling. Domperidone is a dopamine D2 receptor antagonist that enhances gastrointestinal motility and accelerates gastric emptying, helping to alleviate nausea and vomiting commonly associated with pain or NSAID therapy. Zerograin-Plus New is indicated for the management of musculoskeletal pain, dysmenorrhea, and inflammatory conditions where pain relief is required alongside the prevention or treatment of nausea and gastric discomfort. The combination improves patient compliance by addressing both symptoms concurrently. Caution is advised in patients with a history of gastrointestinal ulcers, bleeding disorders, or cardiac conditions. It should be used under medical supervision, particularly in patients with renal or hepatic impairment. Common side effects may include gastrointestinal irritation, dry mouth, dizziness, or headache. Patients should adhere to prescribed dosages and report any adverse reactions promptly.