Wyset-M Tablet is a combination medication containing Levocetirizine 5 mg and Montelukast 10 mg, indicated for the management of allergic conditions such as allergic rhinitis and chronic urticaria. Levocetirizine, a third-generation non-sedating antihistamine, selectively inhibits peripheral H1 receptors, thereby reducing symptoms like sneezing, itching, rhinorrhea, and nasal congestion. Montelukast, a leukotriene receptor antagonist, blocks leukotriene D4 at the cysteinyl leukotriene receptor in the lungs and bronchial tubes, leading to decreased inflammation, bronchoconstriction, and mucus production. The synergistic action of these agents provides comprehensive relief from allergic symptoms by targeting multiple inflammatory pathways. Wyset-M is commonly prescribed for patients who require both rapid symptomatic relief and long-term control of allergic manifestations. It is well-tolerated, with a favorable safety profile; common adverse effects may include headache, fatigue, and gastrointestinal discomfort. Caution is advised in patients with hepatic or renal impairment, and it should be used under medical supervision in pregnant or lactating women. This combination therapy offers an effective and convenient option for improving quality of life in individuals suffering from persistent allergic disorders.