Otena Ear Drop is a topical otic formulation containing Chloramphenicol (5% w/v), Clotrimazole (1% w/v), and Beclometasone (0.025% w/v), designed for the treatment of mixed bacterial and fungal infections of the external auditory canal accompanied by inflammation. Chloramphenicol, a broad-spectrum antibiotic, effectively targets a wide range of Gram-positive and Gram-negative bacteria, inhibiting bacterial protein synthesis to control infection. Clotrimazole, an imidazole antifungal agent, disrupts fungal cell membrane integrity, thereby treating fungal otitis externa. Beclometasone, a potent corticosteroid, provides anti-inflammatory and anti-pruritic effects, reducing edema, erythema, and discomfort associated with otic infections. This combination is particularly beneficial in cases where bacterial and fungal pathogens coexist, and inflammation exacerbates symptoms. Otena Ear Drop should be administered as directed by a healthcare professional, typically instilling the prescribed number of drops into the affected ear(s) after cleaning the ear canal. Caution is advised in patients with tympanic membrane perforation or hypersensitivity to any component. Use during pregnancy and lactation should be under medical supervision. Adverse effects are rare but may include local irritation or hypersensitivity reactions. Proper use ensures effective resolution of otic infections and symptomatic relief.