Only-O Tablet is a combination pharmaceutical formulation containing Domperidone 10 mg and Omeprazole 20 mg, designed for the effective management of gastrointestinal disorders. Domperidone, a peripheral dopamine D2 receptor antagonist, facilitates gastric motility and accelerates gastric emptying, thereby alleviating symptoms such as nausea, vomiting, bloating, and discomfort associated with delayed gastric emptying or gastroparesis. Omeprazole, a proton pump inhibitor, suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells, providing symptomatic relief from acid-related conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and erosive esophagitis. The synergistic action of these two active ingredients offers comprehensive relief by addressing both motility dysfunction and acid hypersecretion. Only-O Tablet is indicated for the treatment of acid reflux, dyspepsia, gastritis, and associated upper gastrointestinal symptoms. It is generally well-tolerated; however, patients should use it under medical supervision, especially those with hepatic impairment, cardiac conditions, or concurrent medications that may interact with domperidone or omeprazole. The recommended dosage and duration should be strictly followed to optimize therapeutic outcomes and minimize potential adverse effects.