Macralfate-O Suspension Sugar Free is a pharmaceutical formulation combining Sucralfate 500 mg and Oxetacaine 10 mg, designed for the management of gastrointestinal mucosal protection and symptomatic relief of pain associated with ulcers and erosive conditions of the upper gastrointestinal tract. Sucralfate acts locally by forming a protective barrier over ulcer sites, thereby shielding the mucosa from acid, pepsin, and bile salts, which facilitates healing and prevents further injury. Oxetacaine, a topical anesthetic, provides rapid analgesic effects by numbing the mucosal surface, effectively reducing pain and discomfort. This sugar-free suspension is particularly suitable for patients requiring glycemic control or those with sugar intolerance. Macralfate-O Suspension is indicated for the treatment of gastric and duodenal ulcers, gastritis, and gastroesophageal reflux disease (GERD) where mucosal protection and pain relief are desired. The combination ensures both therapeutic mucosal protection and symptomatic relief, improving patient compliance and comfort. It is administered orally, with dosing tailored according to clinical response and severity of symptoms. The sugar-free formulation enhances tolerability in diabetic patients and reduces the risk of dental caries. Macralfate-O Suspension Sugar Free should be used under medical supervision, with attention to potential drug interactions and contraindications.