Macprox DP 500 Tablet is a combination medication containing Naproxen 500 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts its therapeutic effect by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for inflammation, pain, and fever. It is commonly indicated for the management of musculoskeletal pain, arthritis, dysmenorrhea, and other inflammatory conditions. Domperidone, a peripheral dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, which helps alleviate nausea, vomiting, and gastric stasis often associated with NSAID therapy. The combination of Naproxen and Domperidone in Macprox DP 500 Tablet offers dual benefits by addressing both pain and gastrointestinal side effects, improving patient compliance and comfort. This medication should be used under medical supervision, with caution advised in patients with a history of gastrointestinal ulcers, cardiovascular disease, or hepatic and renal impairment. Common side effects may include gastrointestinal disturbances, headache, dizziness, and rarely, extrapyramidal symptoms due to Domperidone. It is contraindicated in patients with hypersensitivity to either component and should be avoided during pregnancy and lactation unless prescribed by a healthcare professional.