Lupisoz Tablet contains Esomeprazole 40mg, a proton pump inhibitor (PPI) used primarily to reduce gastric acid secretion. It is indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, and other conditions involving excessive stomach acid production. Esomeprazole acts by irreversibly inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells, thereby suppressing the final step of acid production. This results in a significant and sustained reduction in gastric acidity, promoting healing of acid-related lesions and providing symptomatic relief. Lupisoz is typically administered orally once daily, preferably before meals, to optimize absorption and efficacy. It is generally well tolerated; however, potential adverse effects may include headache, diarrhea, nausea, abdominal pain, and dizziness. Long-term use should be monitored due to possible risks such as vitamin B12 deficiency, hypomagnesemia, and increased susceptibility to gastrointestinal infections. Caution is advised in patients with hepatic impairment, and drug interactions should be reviewed prior to initiation. Lupisoz Tablet is a valuable therapeutic option for managing acid-related gastrointestinal disorders, improving patient quality of life by effectively controlling acid secretion and facilitating mucosal healing.