Lobular+ Cream is a topical formulation combining Ofloxacin (0.75% w/w), Ornidazole (2% w/w), Itraconazole (1% w/w), and Clobetasol (0.05% w/w) designed for the treatment of mixed bacterial, protozoal, and fungal infections accompanied by inflammatory skin conditions. Ofloxacin, a broad-spectrum fluoroquinolone antibiotic, targets susceptible Gram-positive and Gram-negative bacteria by inhibiting DNA gyrase, thereby preventing bacterial replication. Ornidazole, an antiprotozoal agent, is effective against anaerobic protozoa and bacteria, disrupting nucleic acid synthesis. Itraconazole, a triazole antifungal, inhibits ergosterol synthesis, essential for fungal cell membrane integrity, making it effective against dermatophytic and yeast infections. Clobetasol, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, reducing erythema, edema, and itching associated with inflammatory dermatoses. The combination therapy in Lobular+ Cream offers a comprehensive approach to managing polymicrobial skin infections with significant inflammatory components, such as infected eczema, dermatitis, and mixed infections unresponsive to monotherapy. It should be used as directed by a healthcare professional, with caution in prolonged use due to potential corticosteroid-related adverse effects. Avoid application on open wounds or mucous membranes unless prescribed. This formulation is contraindicated in patients with hypersensitivity to any component or in viral skin infections.