Leocet-M Tablet is a combination medication containing Levocetirizine 5mg and Montelukast 10mg, formulated for the management of allergic conditions such as allergic rhinitis and chronic urticaria. Levocetirizine, a third-generation non-sedating antihistamine, selectively inhibits peripheral H1 receptors, thereby reducing symptoms like sneezing, nasal congestion, itching, and rhinorrhea. Montelukast, a leukotriene receptor antagonist, blocks the action of leukotrienes which are inflammatory mediators involved in bronchoconstriction, mucus production, and airway edema. The synergistic effect of these two agents provides comprehensive relief from allergic symptoms by targeting multiple pathways in the inflammatory process. Leocet-M is indicated for patients requiring both antihistaminic and leukotriene receptor antagonist therapy, especially in cases of moderate to severe allergic rhinitis and asthma prophylaxis. The tablet is generally well tolerated, with common side effects including headache, fatigue, and gastrointestinal disturbances. It is contraindicated in patients with known hypersensitivity to either component. Dosage should be as prescribed by a healthcare professional, typically one tablet once daily in the evening. Caution is advised in patients with hepatic or renal impairment. Leocet-M offers an effective therapeutic option for improved symptom control in allergic respiratory disorders.