Koffrio Tablet DT is a combination medication formulated to provide symptomatic relief from common cold and allergy-related conditions. Each tablet contains Phenylephrine 5mg, Chlorpheniramine Maleate 2mg, and Dextromethorphan Hydrobromide 10mg. Phenylephrine acts as a selective alpha-1 adrenergic receptor agonist, effectively reducing nasal congestion by vasoconstriction of the nasal mucosa. Chlorpheniramine Maleate, a first-generation antihistamine, alleviates allergic symptoms such as sneezing, runny nose, and watery eyes by blocking H1 histamine receptors. Dextromethorphan Hydrobromide serves as a centrally acting antitussive, suppressing the cough reflex through its action on the medullary cough center without causing respiratory depression. Koffrio Tablet DT is typically indicated for the relief of nasal congestion, allergic rhinitis, and non-productive cough associated with upper respiratory tract infections. The tablet is designed for rapid disintegration, facilitating ease of administration and prompt onset of action. Caution is advised in patients with hypertension, cardiovascular diseases, glaucoma, or those taking monoamine oxidase inhibitors. Use under medical supervision is recommended to ensure appropriate dosing and to monitor for potential side effects such as dizziness, dry mouth, or drowsiness. Koffrio Tablet DT offers a comprehensive approach to managing multiple symptoms of cold and allergy in a single dosage form.