Justmet GP 1 Forte Tablet PR is a combination oral antihyperglycemic medication containing Glimepiride 1 mg and Metformin 1000 mg, indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, enhances pancreatic beta-cell insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production, improving peripheral glucose uptake, and enhancing insulin sensitivity. The prolonged-release formulation of Justmet GP 1 Forte ensures a steady plasma concentration, optimizing therapeutic efficacy while minimizing gastrointestinal side effects commonly associated with metformin. This combination is particularly beneficial for patients inadequately controlled on diet and exercise alone or those requiring dual therapy to achieve target glycemic levels. It is essential to use this medication alongside lifestyle modifications such as diet and physical activity. Contraindications include patients with renal impairment, hepatic dysfunction, or conditions predisposing to hypoxia. Regular monitoring of blood glucose, renal function, and potential adverse effects like hypoglycemia and lactic acidosis is recommended. Justmet GP 1 Forte Tablet PR should be prescribed and administered under medical supervision to ensure safety and efficacy in managing hyperglycemia in type 2 diabetes mellitus.