Jekpride-MF2 Forte Tablet SR is a combination oral antidiabetic medication containing Glimepiride 2mg and Metformin 1000mg, formulated for sustained release to optimize glycemic control in patients with type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, stimulates pancreatic beta cells to enhance insulin secretion, thereby reducing blood glucose levels. Metformin, a biguanide, primarily decreases hepatic glucose production and improves peripheral insulin sensitivity, contributing to effective blood sugar regulation. The sustained-release formulation ensures a gradual release of active ingredients, minimizing gastrointestinal side effects commonly associated with metformin and providing prolonged therapeutic action. Jekpride-MF2 Forte is indicated as an adjunct to diet and exercise to improve glycemic control in adults inadequately controlled on monotherapy or lifestyle modifications alone. It is essential to monitor blood glucose levels regularly and adjust dosage based on therapeutic response and tolerability. Contraindications include renal impairment, metabolic acidosis, and hypersensitivity to components. Caution is advised in patients with hepatic dysfunction or cardiovascular disease. Common adverse effects may include hypoglycemia, gastrointestinal disturbances, and rarely, lactic acidosis. This combination therapy offers a synergistic approach to managing hyperglycemia, improving patient compliance through once-daily dosing and enhanced efficacy.