Jekpride 1MF Forte Tablet SR is a combination oral antidiabetic medication containing Glimepiride 1mg and Metformin 1000mg, formulated to manage type 2 diabetes mellitus effectively. Glimepiride, a sulfonylurea class agent, stimulates pancreatic beta cells to enhance insulin secretion, thereby reducing blood glucose levels. Metformin, a biguanide, primarily decreases hepatic glucose production and improves peripheral insulin sensitivity, contributing to better glycemic control. The sustained-release (SR) formulation ensures a gradual release of the active ingredients, promoting prolonged therapeutic effects and improved patient compliance by reducing dosing frequency. Jekpride 1MF Forte is indicated for adult patients inadequately controlled by diet and exercise alone or those requiring combination therapy with other antidiabetic agents. It is essential to monitor blood glucose levels regularly during treatment to adjust dosage and prevent hypoglycemia. Common side effects may include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal discomfort, typically transient and manageable. Contraindications include type 1 diabetes, diabetic ketoacidosis, severe renal or hepatic impairment, and hypersensitivity to any component. This medication should be used under strict medical supervision, with consideration for lifestyle modifications and regular monitoring of renal function and glycemic parameters for optimal therapeutic outcomes.