Izra 20 Tablet contains Esomeprazole 20 mg, a proton pump inhibitor (PPI) used to reduce gastric acid secretion by selectively inhibiting the H+/K+ ATPase enzyme system at the secretory surface of gastric parietal cells. It is indicated for the treatment of gastroesophageal reflux disease (GERD), erosive esophagitis, Zollinger-Ellison syndrome, and other conditions associated with excessive stomach acid production. Esomeprazole is effective in promoting healing of erosive esophagitis and providing symptomatic relief of heartburn and acid regurgitation. It is also used in combination with antibiotics for the eradication of Helicobacter pylori infection to reduce the risk of duodenal ulcer recurrence. The recommended dosage for adults typically involves once-daily administration, preferably taken before meals to optimize acid suppression. Izra 20 Tablet should be used with caution in patients with hepatic impairment and is contraindicated in individuals with known hypersensitivity to esomeprazole or other PPIs. Common adverse effects include headache, diarrhea, nausea, and abdominal pain, which are generally mild and transient. Long-term use may be associated with an increased risk of vitamin B12 deficiency, hypomagnesemia, and bone fractures. Patients should consult healthcare providers before initiating therapy to ensure appropriate use and monitoring.