Hefcard 49mg/51mg Tablet
Hefcard 49mg/51mg Tablet
Sacubitril (49mg) + Valsartan (51mg)
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About This Medicine
Product description & overview
Hefcard 49mg/51mg Tablet is a combination medication containing Sacubitril 49mg and Valsartan 51mg, indicated for the treatment of heart failure with reduced ejection fraction (HFrEF). Sacubitril is a neprilysin inhibitor that enhances the effects of natriuretic peptides, promoting vasodilation, natriuresis, and diuresis, thereby reducing cardiac workload and improving cardiac function. Valsartan is an angiotensin II receptor blocker (ARB) that inhibits the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to decreased blood pressure and reduced strain on the heart. The synergistic action of these agents helps to decrease the risk of cardiovascular death and hospitalization due to heart failure. Hefcard is administered orally, typically twice daily, and should be used under strict medical supervision, especially in patients with renal impairment, hypotension, or a history of angioedema. Monitoring of renal function, electrolytes, and blood pressure is recommended during therapy. This combination is contraindicated in patients with a history of hypersensitivity to its components, pregnancy, or concomitant use with ACE inhibitors due to the risk of angioedema. Hefcard 49mg/51mg Tablet represents an important therapeutic option in the management of chronic heart failure to improve clinical outcomes and quality of life.
Active composition
Sacubitril 49 mg
+1 more active ingredient
About Sacubitril
Sacubitril is a neprilysin inhibitor used to treat heart failure. It works by promoting vasodilation and reducing cardiac workload. Sacubitril is effective in managing heart failure symptoms. In summary, Sacubitril is beneficial for treating heart failure.
How It Works
Sacubitril inhibits neprilysin, increasing levels of natriuretic peptides and promoting vasodilation.
All Active Ingredients
Valsartan
Valsartan blocks the action of angiotensin II at its receptor sites, leading to vasodilation and decreased blood pressure.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side Effect Occurrence
Based on clinical trials and patient reports.
Overall Tolerance
Most patients tolerate well
Common Side Effects
Safety Advice
Alcohol
Hefcard 49mg/51mg Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
High Risk
Pregnancy
Hefcard 49mg/51mg Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Medical Advice
Driving
Hefcard 49mg/51mg Tablet should be used with caution in patients with severe kidney disease. Dose adjustment of Hefcard 49mg/51mg Tablet may be needed. Please consult your doctor. Regular blood pressure monitoring is recommended. No dose adjustment is needed in patients with mild to moderate kidney disease.
Exercise Caution
Breastfeeding
It is not known whether Hefcard 49mg/51mg Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react.
Consult Doctor
Kidney
Hefcard 49mg/51mg Tablet should be used with caution in patients with liver disease. Dose adjustment of Hefcard 49mg/51mg Tablet may be needed. Please consult your doctor. However, no dose adjustment is recommended in patients with mild liver disease. Hefcard 49mg/51mg Tablet is contraindicated in patients with severe liver disease.
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