Headmedi-N 500 Tablet is a combination medication containing Naproxen 500 mg and Domperidone 10 mg, formulated to provide effective relief from pain and associated gastrointestinal discomfort. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), exerts analgesic, anti-inflammatory, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing the synthesis of prostaglandins responsible for pain and inflammation. Domperidone, a dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, helping to alleviate nausea and vomiting often associated with pain or NSAID therapy. This combination is particularly useful in managing conditions such as musculoskeletal pain, headaches, dental pain, and dysmenorrhea where inflammation and gastrointestinal side effects coexist. Headmedi-N 500 Tablet should be used under medical supervision, especially in patients with a history of gastrointestinal ulcers, cardiovascular disease, or hepatic and renal impairment. Common adverse effects may include gastrointestinal discomfort, dizziness, and dry mouth. It is contraindicated in patients with known hypersensitivity to either component and should be used with caution during pregnancy and lactation. Proper dosing and adherence to prescribed duration are essential to minimize risks and ensure therapeutic efficacy.