Glypten-M Forte 1000mg/20mg Tablet is a combination oral antidiabetic medication containing Metformin hydrochloride 1000mg and Teneligliptin 20mg, indicated for the management of type 2 diabetes mellitus. Metformin, a biguanide, primarily reduces hepatic glucose production and improves insulin sensitivity, thereby enhancing peripheral glucose uptake and utilization. Teneligliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases endogenous incretin levels, which stimulate glucose-dependent insulin secretion and suppress glucagon release, contributing to improved glycemic control. This combination is beneficial for patients inadequately controlled on Metformin monotherapy or those requiring dual therapy to achieve target glycemic levels. Glypten-M Forte is typically administered once daily with meals to minimize gastrointestinal side effects commonly associated with Metformin, such as nausea and diarrhea. It is contraindicated in patients with severe renal impairment, metabolic acidosis, or known hypersensitivity to its components. Regular monitoring of renal function and glycemic parameters is recommended during therapy. By targeting multiple pathophysiological defects in type 2 diabetes, Glypten-M Forte offers an effective and convenient therapeutic option to improve glycemic control and reduce the risk of diabetes-related complications.