Glyciphage-G 2 Forte Tablet PR is a combination oral antidiabetic medication containing Glimepiride 2mg and Metformin 1000mg, designed for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, stimulates pancreatic beta cells to enhance insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by reducing hepatic glucose production and improving peripheral insulin sensitivity, contributing to decreased blood glucose levels. This dual-action formulation offers complementary mechanisms to achieve optimal glycemic regulation in patients inadequately controlled by diet, exercise, or monotherapy. The prolonged-release (PR) formulation ensures a steady release of active ingredients, promoting better patient compliance and minimizing gastrointestinal side effects commonly associated with metformin. Glyciphage-G 2 Forte is indicated for adult patients with type 2 diabetes who require combination therapy to achieve target glycemic levels. It should be used alongside lifestyle modifications including diet and exercise. Caution is advised in patients with renal or hepatic impairment, cardiovascular disease, or risk factors for lactic acidosis. Regular monitoring of blood glucose, renal function, and potential adverse effects is essential during therapy. This medication should be prescribed and used under medical supervision to ensure safety and efficacy.