Gluconorm-Z XR 60 Tablet

Gluconorm-Z XR 60 Tablet
Gliclazide (60mg) + Metformin (500mg)
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About This Medicine
Product description & overview
Gluconorm-Z XR 60 Tablet is an oral antidiabetic medication formulated with a combination of Gliclazide 60 mg and Metformin 500 mg, designed for the management of type 2 diabetes mellitus. Gliclazide, a sulfonylurea class agent, stimulates pancreatic beta cells to enhance insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production and increasing peripheral insulin sensitivity, contributing to improved glucose uptake and utilization. This extended-release formulation allows for once-daily dosing, promoting better patient compliance and stable plasma drug concentrations. Gluconorm-Z XR 60 is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes inadequately controlled by either agent alone. It is contraindicated in patients with severe renal impairment, diabetic ketoacidosis, or known hypersensitivity to its components. Caution is advised in patients with hepatic dysfunction, cardiovascular disease, or conditions predisposing to hypoxia. Regular monitoring of blood glucose, renal function, and potential adverse effects such as hypoglycemia and gastrointestinal disturbances is recommended. This combination therapy offers a synergistic approach to glycemic management, optimizing efficacy while minimizing side effects associated with higher doses of individual agents.
Active composition
Metformin 500 mg
+1 more active ingredient
About Metformin
Metformin is an oral antihyperglycemic agent used to manage type 2 diabetes mellitus. It works by decreasing glucose production in the liver and improving insulin sensitivity. Metformin is effective in controlling blood sugar levels and preventing diabetes-related complications. In summary, Metformin is vital for managing type 2 diabetes.
How It Works
Metformin reduces hepatic glucose production and enhances peripheral insulin sensitivity, lowering blood glucose levels.
All Active Ingredients
Gliclazide
Gliclazide stimulates insulin secretion from pancreatic beta cells and enhances insulin sensitivity in peripheral tissues.
Dosage & How to Use
Dosage information not available. Please consult your doctor or pharmacist.
Safety Advice
Important precautions
Side Effect Occurrence
Based on clinical trials and patient reports.
Overall Tolerance
Most patients tolerate well
Common Side Effects
Safety Advice
Alcohol
It is unsafe to consume alcohol with Gluconorm-Z XR 60 Tablet.
High Risk
Pregnancy
Gluconorm-Z XR 60 Tablet is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.
Medical Advice
Driving
Your ability to drive may be affected if your blood sugar is too low or too high. Do not drive if these symptoms occur.
Exercise Caution
Liver
Gluconorm-Z XR 60 Tablet should be used with caution in patients with liver disease. Dose adjustment of Gluconorm-Z XR 60 Tablet may be needed. Please consult your doctor. Gluconorm-Z XR 60 Tablet is generally started with low dose in patients with mild to moderate liver disease and its use is not recommended in patients with severe liver disease.
Regular Checkup
Breastfeeding
Gluconorm-Z XR 60 Tablet is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.
Consult Doctor
Kidney
Gluconorm-Z XR 60 Tablet should be used with caution in patients with kidney disease. Dose adjustment of Gluconorm-Z XR 60 Tablet may be needed. Please consult your doctor. Use of Gluconorm-Z XR 60 Tablet is, however, not recommended in patients with severe kidney disease. Regular monitoring of kidney function test is advisable while you are taking this medicine.
Regular Checkup
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