Gluconorm-G 1 Forte Tablet PR is a combination oral hypoglycemic agent containing Glimepiride 1mg and Metformin 1000mg, indicated for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class drug, stimulates pancreatic beta cells to enhance insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production and increasing peripheral insulin sensitivity, contributing to improved glucose uptake and utilization. This synergistic combination targets multiple pathophysiological defects in type 2 diabetes, facilitating effective blood glucose regulation. Gluconorm-G 1 Forte Tablet PR is typically prescribed when monotherapy with either agent is inadequate to achieve glycemic targets. It is essential to administer the medication with meals to minimize gastrointestinal side effects commonly associated with Metformin, such as nausea and diarrhea. Patients should be monitored for signs of hypoglycemia due to the insulin secretagogue effect of Glimepiride, particularly in the elderly or those with renal impairment. Regular assessment of renal function, liver enzymes, and blood glucose levels is recommended during therapy. This formulation offers a convenient once-daily dosing regimen, enhancing patient compliance in the long-term management of type 2 diabetes mellitus.