Glipol Tablet contains Glibenclamide 5mg, a sulfonylurea class oral hypoglycemic agent used in the management of type 2 diabetes mellitus. It functions by stimulating insulin secretion from pancreatic beta cells, thereby reducing blood glucose levels. Glipol is indicated for patients with type 2 diabetes who have inadequate glycemic control through diet and exercise alone. It is particularly effective in patients with residual pancreatic function. The dosage should be individualized based on patient response, typically starting with a low dose to minimize the risk of hypoglycemia. Common side effects include hypoglycemia, weight gain, gastrointestinal disturbances, and allergic skin reactions. Caution is advised in patients with hepatic or renal impairment, as altered metabolism and excretion may increase the risk of adverse effects. Glipol should not be used in type 1 diabetes, diabetic ketoacidosis, or during pregnancy and lactation unless clearly necessary. Patients should be educated on recognizing symptoms of hypoglycemia and advised to maintain regular meal patterns. Drug interactions with other hypoglycemic agents, beta-blockers, and certain antibiotics may potentiate or diminish its effect. Regular monitoring of blood glucose and periodic assessment of renal and hepatic function are recommended to ensure safe and effective therapy.