Glimebees-M 1 Forte SR Tablet is a combination oral antidiabetic medication containing Glimepiride 1mg and Metformin 1000mg, designed for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, functions by stimulating pancreatic beta cells to increase insulin secretion, thereby lowering blood glucose levels. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production, enhancing peripheral glucose uptake, and improving insulin sensitivity. The sustained-release formulation of Metformin in Glimebees-M 1 Forte SR ensures a gradual release of the drug, promoting better glycemic control with reduced gastrointestinal side effects commonly associated with immediate-release metformin. This combination therapy is indicated for patients inadequately controlled on diet and exercise alone or those who have failed monotherapy with either agent. It is essential to monitor blood glucose levels regularly and adjust the dosage based on therapeutic response and tolerability. Caution is advised in patients with renal impairment, hepatic dysfunction, or conditions predisposing to hypoxia or lactic acidosis. Glimebees-M 1 Forte SR should be used as part of a comprehensive diabetes management plan, including diet, exercise, and regular monitoring to minimize the risk of complications associated with type 2 diabetes mellitus.