Gliaid 2 Forte Tablet PR is a combination oral antidiabetic medication containing Glimepiride 2 mg and Metformin 1000 mg, designed for the management of type 2 diabetes mellitus. Glimepiride, a sulfonylurea class agent, stimulates pancreatic beta cells to increase insulin secretion, thereby improving glycemic control. Metformin, a biguanide, primarily acts by decreasing hepatic glucose production and enhancing peripheral insulin sensitivity, which contributes to improved glucose uptake and utilization. This dual mechanism addresses both insulin deficiency and insulin resistance, making Gliaid 2 Forte effective in achieving optimal blood glucose levels in patients inadequately controlled by diet and exercise alone. The prolonged-release formulation ensures a steady plasma concentration, reducing the risk of hypoglycemia and gastrointestinal side effects commonly associated with immediate-release metformin. Gliaid 2 Forte is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes when monotherapy with either agent is insufficient. It should be used with caution in patients with renal impairment, hepatic dysfunction, or cardiovascular disease. Regular monitoring of blood glucose, renal function, and lactic acid levels is recommended to minimize adverse effects. Patient adherence to lifestyle modifications alongside pharmacotherapy is essential for optimal therapeutic outcomes.