Esoclock-DSR Capsule is a combination pharmaceutical formulation containing Domperidone 30mg and Esomeprazole 40mg, designed for the management of gastroesophageal reflux disease (GERD), dyspepsia, and related upper gastrointestinal disorders. Domperidone, a peripheral dopamine D2 receptor antagonist, enhances gastrointestinal motility and accelerates gastric emptying, thereby alleviating symptoms such as nausea, vomiting, and bloating. Esomeprazole, a proton pump inhibitor (PPI), suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in the gastric parietal cells, promoting mucosal healing and symptom relief in acid-related conditions. The dual-action mechanism of Esoclock-DSR Capsule provides both symptomatic relief and addresses the underlying pathophysiology of acid reflux and delayed gastric emptying. It is indicated for patients requiring both acid suppression and prokinetic therapy, especially in cases where monotherapy is insufficient. The extended-release formulation ensures sustained therapeutic plasma concentrations, improving compliance and efficacy. Esoclock-DSR should be used under medical supervision, with caution advised in patients with cardiac arrhythmias, hepatic impairment, or those on medications that may interact with domperidone or esomeprazole. Common adverse effects include headache, dry mouth, and gastrointestinal disturbances. Regular monitoring is recommended during prolonged therapy.