Zytor-Plus 20 Tablet is a combination medication containing Spironolactone 50 mg and Torasemide 20 mg, indicated primarily for the management of edema associated with congestive heart failure, liver cirrhosis, and nephrotic syndrome. Spironolactone, a potassium-sparing diuretic and aldosterone antagonist, acts on the distal renal tubules to promote sodium and water excretion while conserving potassium, thereby preventing hypokalemia. Torasemide, a loop diuretic, inhibits the Na-K-2Cl symporter in the thick ascending limb of the loop of Henle, resulting in potent diuresis and reduction of fluid overload. The synergistic effect of these agents provides effective control of fluid retention and reduces blood pressure in hypertensive patients. Zytor-Plus 20 is beneficial in patients requiring enhanced diuresis without excessive potassium loss. It is essential to monitor electrolyte levels, renal function, and blood pressure regularly during therapy to avoid adverse effects such as hyperkalemia, dehydration, or renal impairment. Contraindications include anuria, acute renal insufficiency, hyperkalemia, and hypersensitivity to either component. Use with caution in patients with hepatic impairment or diabetes mellitus. This combination should be used under medical supervision with appropriate dose adjustments based on clinical response and laboratory parameters.