Zubinor-PG Tablet SR is a sustained-release formulation combining Pregabalin 75 mg, Nortriptyline 10 mg, and Methylcobalamin 1500 mcg, designed to provide comprehensive management of neuropathic pain and associated neurological conditions. Pregabalin, a gamma-aminobutyric acid (GABA) analogue, modulates calcium channels to reduce neurotransmitter release, thereby alleviating neuropathic pain and improving nerve function. Nortriptyline, a tricyclic antidepressant, enhances noradrenaline and serotonin levels in the central nervous system, contributing to pain relief and mood stabilization. Methylcobalamin, an active form of vitamin B12, supports nerve regeneration and repair by promoting myelin sheath synthesis and neuronal metabolism. The combination in Zubinor-PG Tablet SR offers synergistic effects targeting multiple pathways involved in neuropathic pain, making it suitable for conditions such as diabetic neuropathy, post-herpetic neuralgia, and peripheral neuropathy. The sustained-release formulation ensures prolonged therapeutic plasma concentrations, improving patient compliance and minimizing dosing frequency. Zubinor-PG should be used under medical supervision, with dosage adjustments based on clinical response and tolerability. Common adverse effects may include dizziness, dry mouth, and gastrointestinal disturbances. This combination therapy provides an effective option for patients requiring multimodal neuropathic pain management with neuroprotective benefits.