Zomidol-SP Tablet is a combination analgesic and anti-inflammatory medication containing Aceclofenac 100 mg, Paracetamol 325 mg, and Serratiopeptidase 15 mg. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory, analgesic, and antipyretic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol provides effective analgesia and antipyresis through central inhibition of prostaglandin synthesis, complementing the peripheral action of Aceclofenac. Serratiopeptidase, a proteolytic enzyme, facilitates the breakdown of inflammatory mediators and promotes the resolution of edema and inflammation by enhancing tissue permeability and drainage of exudates. This combination is indicated for the management of acute and chronic musculoskeletal pain, osteoarthritis, rheumatoid arthritis, postoperative inflammation, and other inflammatory conditions where pain relief and reduction of swelling are desired. Zomidol-SP offers a synergistic approach by addressing pain, inflammation, and associated edema, improving patient comfort and mobility. It should be used under medical supervision, considering contraindications such as hypersensitivity to NSAIDs, active gastrointestinal ulcers, bleeding disorders, and severe hepatic or renal impairment. Adverse effects may include gastrointestinal discomfort, allergic reactions, and rarely, hepatic or renal dysfunction. Patient adherence to prescribed dosage and monitoring is essential for optimal therapeutic outcomes.