Zoletar Lotion is a topical pharmaceutical formulation containing Ketoconazole 2% w/v and Coal Tar 2% w/v, indicated for the treatment of various dermatological conditions characterized by fungal infections and inflammatory skin disorders. Ketoconazole, an imidazole antifungal agent, exerts its effect by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes, thereby disrupting membrane integrity and leading to fungal cell death. Coal Tar, a byproduct of coal distillation, possesses anti-inflammatory, antipruritic, and keratoplastic properties, making it effective in reducing scaling, itching, and inflammation associated with psoriasis, seborrheic dermatitis, and other chronic skin conditions. The combination of these two active ingredients provides a synergistic therapeutic effect, targeting both fungal pathogens and inflammatory symptoms. Zoletar Lotion is applied topically to the affected area once or twice daily, depending on clinical severity and physician recommendation. It is generally well tolerated; however, patients should be advised to avoid contact with eyes and mucous membranes and to discontinue use if irritation or hypersensitivity reactions occur. Caution is advised in patients with known hypersensitivity to either component. Zoletar Lotion offers an effective treatment option for managing fungal infections complicated by inflammatory dermatoses, improving patient outcomes through its dual-action mechanism.