Zix-RP Capsule is a combination medication containing Aceclofenac (100mg), Paracetamol (325mg), and Rabeprazole (10mg), designed for the management of pain, inflammation, and gastric acid-related disorders. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent anti-inflammatory and analgesic effects by inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis. Paracetamol provides additional analgesic and antipyretic benefits, enhancing pain relief while minimizing the dose of NSAIDs required. Rabeprazole, a proton pump inhibitor, reduces gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells, thereby protecting the gastric mucosa from NSAID-induced irritation and ulceration. This combination is particularly useful in patients requiring effective pain and inflammation control with a reduced risk of gastrointestinal complications. Zix-RP Capsule is indicated for conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other musculoskeletal disorders associated with pain and inflammation. It should be used under medical supervision, with caution in patients with a history of gastrointestinal disorders, hepatic or renal impairment, or hypersensitivity to any component. Regular monitoring and adherence to prescribed dosage are essential to optimize therapeutic outcomes and minimize adverse effects.