Zix-R OD Capsule SR is a combination pharmaceutical formulation containing Aceclofenac 200 mg and Rabeprazole 20 mg, designed for the management of inflammatory and acid-related gastrointestinal conditions. Aceclofenac, a non-steroidal anti-inflammatory drug (NSAID), exerts potent analgesic and anti-inflammatory effects by selectively inhibiting cyclooxygenase enzymes, thereby reducing prostaglandin synthesis responsible for pain and inflammation. Rabeprazole, a proton pump inhibitor (PPI), suppresses gastric acid secretion by irreversibly inhibiting the H+/K+ ATPase enzyme system in gastric parietal cells, promoting mucosal healing and preventing NSAID-induced gastropathy. The sustained-release (SR) formulation ensures prolonged therapeutic plasma concentrations, enhancing patient compliance through once-daily dosing. Zix-R OD Capsule SR is indicated for the treatment of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, and other musculoskeletal disorders requiring anti-inflammatory therapy, particularly in patients at risk of developing NSAID-associated gastric ulcers or dyspepsia. Caution is advised in patients with hypersensitivity to NSAIDs or PPIs, hepatic or renal impairment, and cardiovascular disease. Common adverse effects may include gastrointestinal discomfort, headache, dizziness, and rare hypersensitivity reactions. This combination should be used under medical supervision with periodic monitoring to optimize therapeutic outcomes and minimize potential risks.