Zincort GC Neo Cream is a topical formulation combining Clotrimazole (1% w/w), Clobetasol propionate (0.05% w/w), and Neomycin sulfate (0.5% w/w), designed for the effective management of mixed fungal and bacterial skin infections accompanied by inflammatory conditions. Clotrimazole, an imidazole antifungal agent, inhibits the synthesis of ergosterol, disrupting fungal cell membrane integrity and thereby exerting broad-spectrum antifungal activity against dermatophytes, yeasts, and molds. Clobetasol propionate, a potent corticosteroid, provides anti-inflammatory, antipruritic, and vasoconstrictive effects, reducing erythema, swelling, and itching associated with inflammatory dermatoses. Neomycin sulfate, an aminoglycoside antibiotic, targets susceptible gram-negative and some gram-positive bacteria by inhibiting protein synthesis, thus preventing secondary bacterial infections. The synergistic combination in Zincort GC Neo Cream facilitates rapid symptom relief and promotes resolution of complex cutaneous infections with inflammatory components. It is indicated for conditions such as tinea infections with secondary bacterial involvement and inflammatory dermatoses complicated by microbial colonization. Usage should be limited to the prescribed duration to minimize potential adverse effects, including corticosteroid-induced skin atrophy and antibiotic resistance. Patients should avoid application on broken skin or mucous membranes and consult a healthcare professional if symptoms persist or worsen.